Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone

J Med Chem. 1998 Oct 22;41(22):4181-5. doi: 10.1021/jm980192x.
No abstract available

MeSH terms

  • Animals
  • Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry
  • Bridged Bicyclo Compounds, Heterocyclic / pharmacology
  • Crystallography, X-Ray
  • Cyclic AMP / biosynthesis
  • Guinea Pigs
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Hydrolysis
  • In Vitro Techniques
  • Models, Molecular*
  • Molecular Conformation
  • Muscarinic Agonists / chemical synthesis*
  • Muscarinic Agonists / chemistry
  • Muscarinic Agonists / pharmacology
  • Myocardium / metabolism
  • Phosphatidylinositols / metabolism
  • Rats
  • Spiro Compounds / chemical synthesis*
  • Spiro Compounds / chemistry
  • Spiro Compounds / pharmacology
  • Structure-Activity Relationship

Substances

  • Bridged Bicyclo Compounds, Heterocyclic
  • Muscarinic Agonists
  • Phosphatidylinositols
  • Spiro Compounds
  • dihydro-4'-methylspiro(1-azabicyclo(2.2.1)heptane-3,5'(4'H)-furan)-3'-one
  • Cyclic AMP